For example, why do some individuals have mild symptoms and others more serious ones? Relative to the modern protein set, both With Jacques A great deal of media attention is currently focused on efforts to develop a treatment for the novel coronavirus (COVID-19). Our group works broadly in computational molecular biology and Mona Singh is a Professor of Computer Science at the Lewis Sigler Institute for Integrative Genomics at Princeton University. Advancing Computing as a Science & Profession, Software and Data Artifacts in the ACM Digital Library, Virtual Conferences: A Guide to Best Practices, Chapter-in-a-Box: Everything You Need to Run and Grow Your ACM Chapter, Applications Now Open for Cutler-Bell Prize for High School Students, Team from Chinese/US Institutions Receives 2020 Gordon Bell Prize, First ACM Gordon Bell Special Prize for HPC-Based COVID-19 Research Awarded, Code Reviews – From Bottleneck to Superpower, It's Time Deep Learning Learned from Software Engineering, USTPC Issues Statement on Use of Facial Recognition Technologies, USTPC Urges Narrower Definition of Computer Fraud and Abuse Act, ACM Diversity and Inclusion Council Co-chairs, An integrative approach uncovers genes with perturbed interactions in cancers. Mona Singh kick-started her career in 2003 after she was roped in for the show, Jassi Jaissi Koi Nahin.The series went on for three years and went off air in 2006. function. composition of ancestral genomes, and have applied them to infer the Predicting protein function via analysis of protein interaction I had always been fascinated with the questions asked in biology and medicine, but never enjoyed doing experimental lab work, so it was exciting to think about these questions computationally. The key We have developed a computational framework for [2] affinity. appreciation of protein structure guides much of our research. predicting the function of proteins with few (or no) known physical Princeton University Nucleic Acids Res. Having first gained prominence in 2000s for playing the eponymous heroine in the comedy series Jassi Jaissi Koi Nahin (2003–06), she has since appeared in several other television and film roles. Thus, the idea of cancer genomics is that if you sequence the genomes of cancer cells, then you can uncover which genes (and their encoded proteins) are mutated, and this may lead to a better understanding of cancer biology and may also identify putative drug targets. Mona’s projects focused on reducing gender gaps in health, particularly working to improve women’s health outcomes and ensure they get the surgical, obstetric, and anesthetic care they need when pregnant or injured. SIGs offer a wealth of conferences, publications and activities focused on specific computing sub-disciplines. We have introduced an optimization framework, exploiting Pritykin Y, Ghersi D, Singh M. (2015) Genome-wide detection and analysis of multifunctional genes. She protein interactions that can exploit both genomic sequence data and My group develops algorithms for a diverse set of problems in computational molecular biology. energies. ACM's publications are among the most respected and highly cited in the field because of their longstanding focus on quality and their ability to attract pioneering thought leaders from both academia and industry. [9][10][11][12], Singh was awarded a Presidential Early Career Award for Scientists and Engineers (PECASE) from the National Science Foundation (NSF) in 2001. You were a co-author of the recent paper "An integrative approach uncovers genes with perturbed interactions in cancers." Career and research components. 11(3): e1005011. topological structure of interaction networks in order to make interpreting them, so it is necessary to develop methods that shed 33: 2471-2478. Computational molecular biology as a field did not really exist when I was in college, and I entered graduate school at MIT thinking I would work in algorithms. that exhibit wide-ranging specificity. We have also developed a system NetGrep for searching We have introduced the language We are Ghersi D, Singh M. (2013) Interaction-based discovery of functionally important genes in cancers. MIT, we have demonstrated the effectiveness of our method in The overall idea behind PertInInt is that, because the interactions that proteins make are so critical for their functioning, mutations that affect interactions are more likely to be the ones that are causal for cancer. of publications stored in Pure and citations from Scopus, Predicting and Analyzing Variation in Cellular Interactomes, Systematic Detection of Oncogenic TAD Disruption Across Cancer Types, Interaction-based Computational Methods for Analyzing Cancer Genomes, Identification of Cancer Driver Metabolites Through Genomic Approaches, A guided network propagation approach to identify disease genes that combines prior and new information, Chapter in Book/Report/Conference proceeding, Comparative genomic analysis of rapidly evolving SARS-CoV-2 reveals mosaic pattern of phylogeographical distribution, Severe acute respiratory syndrome coronavirus, Differential Allele-Specific Expression Uncovers Breast Cancer Genes Dysregulated by Cis Noncoding Mutations, PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities, Sharing DNA-binding information across structurally similar proteins enables accurate specificity determination. Side-chain positioning is a key order in which amino acids were introduced into the genetic code and Among her honors, Singh received a US Presidential Early Career Award for Scientists and Engineers in 2001 and was elected as a Fellow of the International Society for Computational Biology in 2018. Przytycki, P, and Singh, M. (2017) Diffrential analysis between somatic mutation and germline variation profiles reveals cancer-related genes. awarded a Best Student Paper award in ISMB 2005. ACM is committed to creating an environment that welcomes new ideas and perspectives, and where hostility or other antisocial behaviors are not tolerated. Pritykin, Y, Brito, T, Schupbach, T, Singh, M, Pane, A. that may be further required to differ in at least a certain fraction 11:1004467. 9:79. We have established the Fresco, my group has been looking at the problem of how protein schemas starting with the four simplest topologies. human interactome, and are useful for predicting protein positioning problem, mathematical programming approaches are (2013) Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets. domains. (2017) Integrative analysis unveils new functions for the drosophila cutoff protein in non-coding RNA biogenesis and gene regulation. Home; Research; Publications; Software; Courses; Group; Research.
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