INTRODUCTION This reaction was first reported by Clemmensen of Park Davis in 1913. Mechanism of the Clemmensen Reduction. The reduction, however, fails with acid-sensitive and high molecular weight substrates. Mechanism of Clemmensen Reduction Reaction: The mechanism of this reaction is not completely understood, but there are two proposals; Carbanionic mechanism: The carbanionic mechanism of reaction shows that the zinc attacks directly to the protonated carbon. The reduction takes place at the surface of the zinc catalyst. The reaction mechanism of Clemmensen reduction has not completely been clarified, but it is well known that the alcohol is not an intermediate. The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene groups.In the context of complex molecule synthesis, it is most frequently employed to remove a carbonyl group after it has served its synthetic purpose of … A single electron reduction of the ketone takes place to give a radical anion. In this reaction, alcohols are not postulated as intermediates, because subjection of the corresponding alcohols to these same reaction conditions does not lead to alkanes. The α, β-unsaturated ketones undergo reduction of both the olefinic and carbonyl groups. The mechanism for the Clemmensen reduction is not yet fully understood and there are two popular proposals.    This reaction is named after Erik Christian Clemmensen , a Danish chemist. The Clemmensen Reduction can effect a similar conversion under strongly acidic conditions, and is useful if the starting material is base-labile. The first one is called the carbanionic mechanism, where the … The reaction mechanism of Clemmensen’s reduction is still debatable on certain levels, but a majority of the scientific community accepts the following mechanism. The Danish chemist discovered this reaction named Erik Christian Clemmensen. The first one is called the carbanionic mechanism, where the … The reduction may take place through two possible mechanisms. Clemmensen reduction is a chemical reaction described as a reduction of ketones (or aldehydes) to alkanes using zinc amalgam and concentrated hydrochloric acid. It is the reduction of carbonyl groups ( in aldehyde and ketone) to methylene group. This reaction is named after Erik Christian Clemmensen, a Danish chemist. The mechanism for the Clemmensen reduction is not yet fully understood and there are two principal proposals: the ‘Carbanionic Mechanism’ and the ‘Carbenoid Mechanism’. Reaction Mechanism of Clemmensen Reduction Mechanism of the Wolff-Kishner Reduction… After a critical review, we present a complete and coherent reaction mechanism that involves the formation of a free carbene as well as a zinc carbene and two different carbanionic species as intermediates. The Clemmensen reduction is an organic reaction used to reduce an aldehyde or ketone to an alkane using amalgamated zinc and hydrochloric acid. Mechanism of Clemmensen Reduction. * There is a net flow of electrons from zinc to the carbonyl compound. The key steps of the mechanism are given below, crucially showing that the alcohol is not an intermediate (hence why secondary alcohols are not able to undergo a Clemmensen reduction to afford the corresponding alkane). MECHANISM OF CLEMMENSEN REDUCTION * The Clemmensen reduction occurs over the surface of zinc catalyst. Clemmensen reduction is an organic reaction which leads to the formation of alkanes by reduction of aldehydes or ketones in presence of acid and with amalgamated zinc. Clemmensen Reduction of aldehydes and ketones by Zn(Hg), HCl. Clemmensen Reduction acid alcohol aldehyde alkane acid alkane (–1C) CH3 Samarium Iodide Ionic Hydrogenation (Et3SiH, TFA) Luche Reduction (NaBH4, CeCl3) ** 1. The probable mechanism is shown below. This reduction is also observed in Wolff-Kishner reduction but Clemmensen reduction is easier to perform. The reduction may take place through two possible mechanisms. C=O group of aldehydes and ketones is reduced to -CH 2-group by clemmensen reduction. The reaction mechanism of Clemmensen reduction has not completely been clarified, but it is well known that the alcohol is not an intermediate. The mechanism of this reaction is not studied widely, which is a limitation of Clemmensen reduction. This reaction done with zinc amalgam and hydrochloric acid and it is generally known as Clemmensen reduction. Mechanism of Clemmensen Reduction. Zinc amalgam and concentrated hydrochloric acid ( Zn(Hg) / concentrated HCl ) is used as the reagent for clemmensen reduction. The mechanism for the Clemmensen reduction is not yet fully understood and there are two principal proposals: the 'Carbanionic Mechanism' and the 'Carbenoid Mechanism'. * The Clemmensen reduction is complementary to Wolff-Kishner reduction, which may be used to reduce acid sensitive compounds. #amsonlinechemistry #Clemmensen_reduction_with_mechanism #Reduction_of_Aldehyde_&_ketones_to_Hydrocarbons #intermidiate_chemistry. The mechanism of this reaction is not studied widely, which is a limitation of Clemmensen reduction. Clemmensen reduction is a chemical reaction described as a reduction of ketones (or aldehydes) to alkanes using zinc amalgam and concentrated hydrochloric acid.
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